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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16a6f83d0984b08b0e3c1183048262c86a8cd9c1035716021a6378dc05969b50' 
  AND token = 'O3VF21vTEbRyn4FKNjd0pPukob2WtjW2pDwNnicQN60=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}