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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e43d134f1b957268c57b7c72c5dad26f8f0051dac83a691b7d4047120b6be78' 
  AND token = 'jNR/Iv/glta0ZS/+aC4Caiij1azgfDW0026AV8c87aw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}