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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5a16027df4e42767a594d5b39e5d4b41a5300b3ac9523489e212020309afc2da' 
  AND token = 'F9ouOt8+HhkFLHOB4/bVfLSXSwU2ipdvjE0JJsleTio=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}