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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '459a3fa996c91228697e8c20414f722f484c2de77da5fb5f7e428b930d71c6b4' 
  AND token = 'vGHNdAX1k0VDjTCsGc9bTxJu1RK9eR5PiCk34/b2UlE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}