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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42f7635cd533f629fbc8bf00c97d991b37f7ef447446d3979eadfd8a1e18c161' 
  AND token = 'fizzp78etQJBSpEtvWS4AdmPtdkPQT2caRIuY8984Ak=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}