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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72a4a562821ddb8a713775d0f7984f187275413a936e83307c0879a1c12648f3' 
  AND token = 'EA++6nkSk4TfUEIu3GX0zDmyy7GFMCv4fC463XaOJIE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}