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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de07e15e5fb0ee2c08e756becf7bcc471d9b37fb01fd9d081746437019c79728' 
  AND token = 'wzcY4Xu7v/+UCx+h8p0oUsTDkNqayqXbe5Abo0ACf0s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}