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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4c9a49fdb28750cbf02c2d2d7ee867ab276256742826aa31e3d4af418c459880' 
  AND token = 'OpCy9NgdC/0Dz3Kp0IQLCW6k05WtY0rruyyh5ZTNXKg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}