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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '09458251fcc6781770794491187e78798d859292273582aeb6378e79f87271da' 
  AND token = 'dG1w3KMq7ts+8MKBd8syy9vQpLK6P2IotZqnDbXT0Ho=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}