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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c64797f252a3f1086dc41725c48c4cc7a3129ffaee4359095ee08192999f6868' 
  AND token = '7Y5PM1L0wYT6zPUrj7m3wAagbuboHhDWDXauxnOwPsI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}