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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1fc10be45c5a33b311999bfe57dbb882e2d70b0ee89074567cb106ebfd925c9f' 
  AND token = 'GHJBO2Z/+O+TN50NWeiAQCC3pjd+F1kcEnD1mEc9qZg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}