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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22a3e5bccb9a27912d33e15c4f268c2916b427040aa7917da74eba60203cc1e4' 
  AND token = 'wyGyPVOqYTDElUeO9UX6CeM6niXGWEP0mm0mDQaZZOA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}