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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '422821160fc471cf0268eda5c69f0fcb1ad435fed2526e6d7b64407d90aa9100' 
  AND token = '0WQTqjYkBu3a7YyqjHeReDVc1ThAc5PPgDlLwEWJrQM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}