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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2763c627044ff696b56fd54eb6eb608298ec93160c5c1e64608308e946c01d4c' 
  AND token = '0Qwz/cKX/y3wEA0tyIi5C5L+nbUzWI30oSuRUxJSFVo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}