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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53ee296f722f1cf9795cccc5e2a16ede9a3e834907225abefb98515617c350a7' 
  AND token = 'VzSrCwWB5N8m7WrPgeviBM1i00EM2A2JvRONWfk0YXk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}