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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0378daafb821b1136724069bb3eddfc527c4fd415dee243264f8cfe48fcd988f' 
  AND token = '0R8mdpgshxUCTaA9G3AcHwKLXdiQYaf/qK0SKJnVsuc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}