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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65ced375c38ec65ccd2e89332a806739d8f62d2f7d9ef8076570fe4ade697254' 
  AND token = 'BPQn5AGTpEBVdK2PMO5zNPzltk8L+aL8VDlIwdOXDoI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}