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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3f908f81ae9c83b0c95bbf474c54803e83173e6a6782ba201b3a584239e8cb75' 
  AND token = 'UMVKtA1aTqZ/OjW9Co3CD7bSsNCVAwVavYc45BFhROo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}