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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80fa39c80417701a256f21b9c59dd5d840e8b328a67b21443e882c16f750d568' 
  AND token = 'fYjQ1+I44+ZL+9rkw+6bo62TM3giGNxvkwbt/TYHoM8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}