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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21fb8d5ea1a2578ec36f7c1d1701c5840f4e22b8ff6c7997a813b63435114279' 
  AND token = 'Tex03DV/qCKx04bSZQtSNgqu2irdXqZHLXBRDmZt8y4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}