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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b2408a9a481c96a759fbfffb3161c90c942274e0ed5128adaa2010630ec02dc' 
  AND token = 'hzX42FCu/++u81T/h4mUD//gjjyz8vmbYhD7fTYLu2Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}