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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78b462a68e9a18f02a1497ff5a20ef2e209a3f4c05a37318498912efdb7c6e14' 
  AND token = 'kL2xBySABTH05pX0PbnKBlSd45YcymcvmRiimyXBEes=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}