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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78abf7e086b6fc7cdfe878b60741493f33512b3ae041d0ded7faf8a605e39e4d' 
  AND token = 'kE4N25XxzX93T6P3x0fFK1gFl5NyVw8Fx9Xm7zJfrpU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}