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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a5b726f933c1ff45196eb94ad01a5c8bebce5cb9d0e111b3aa2a67339497638b' 
  AND token = '3qFNThbPCiEnkQ3s195LbxLfD0wZgfb7sxJaSW9ZL5c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}