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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f2eca29ffe06ad9e2767d7bc8a828b242b96ab7052c0a8357a7b145e250c3023' 
  AND token = 'igCItq0h71rPIlBjDQ+D9C3ZYvWW6b3XRf470CTRXdg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}