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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6a8e5f72ff3c157a5ce1faa8c92c584274e32ba5d525f0a9f4c0dedd8170a296' 
  AND token = 'UF03Wt2YhqEkWRMMNo1pxxCi5Jb+GUSmfrCecelgdfA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}