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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8f4b0fa31911387a81e08decfd7c93e896f96a789c3348c0736e92177d77b49f' 
  AND token = '3+4M5flCCb5n0lS0tsCeBVwEpkX/zRxvX31Mq16Z7kE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}