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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1888a60ab424324ac78e10fa9d0bf3f68e6c2df336681afe5c19aae2bc1096af' 
  AND token = 'CLM4Q7x9kI/hicOXNUusfqWkm9t+L/U6sYCBPjYgXV8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}