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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48288c48b21df01b8a3c23757f6f9492b18ba1ed4aeae17d31d2eec0b644121a' 
  AND token = '29PJ/zV3gjyKoO2g8N//Bwln7PczO/Hf2XHg71VoAM4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}