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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '350d284a08c936c46fa9e2680f11f1c976dec3c738fd71ae945134aca2ba8dba' 
  AND token = '7k2jqMhZ9EkH072Ye/Ky1gM9RTA0KKzbDQwz7Iyo78c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}