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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1def9d82a269e259732988419332102356a69f10b2ea024ddd508dd8ebd80e1e' 
  AND token = 'bdCU+5IDbHFj2z/b+iBpPfA8QhFVpV1DhDNenQ/dLHE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}