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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4104a1a60c52e7752f4c8f759c591659f729a185b7fa189af3680771e87ab39f' 
  AND token = 'DU/wTj7zhnpi7I0BTw0/chsIulaml+JIJsSEW4n51+Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}