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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c0aa53f465111a9abcfeb86e2f022fd7c0b72d60b0a314dc40185cfb8f1c8447' 
  AND token = '43/wxIPfcgj0z0fdeJQkUQ1ifk/V1e96zR9sO8Je6fQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}