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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2f5481f54145fb787102b3f2f175a76a226f4500ff503c5459e6d2bf52d9afce' 
  AND token = 'ZWryhjdawywCeI3ghCFnPC8XDxx/AvaQ1TVbH/E0ZgM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}