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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4fd9afd8112675e650e96c717c02411f20602bb97677cdf103005dcf7c9b2a21' 
  AND token = 'zIL/zc+I9+5k55eOTYzVDXKRT7xCz5mH0TuXLAwbl40=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}