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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42241de071358cb0754d58ceb43693f2168be0180cfbc1c37b2fe3ca19c47d0c' 
  AND token = 'JsKql2sK/4BOZCx4mAHu6CRwsKEp6rB7Ez9p8a2ir2Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}