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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7812b73f0c6e6b5b0be2fb75f3f0a021643453852b5a4c6485a8afcf8736324b' 
  AND token = 'IsioZaxJlIVPLsMfOVsd+mCzrR8T+vm2EO8zEzMmaX0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}