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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4fd9152da67e0aaf1c41bce9cd0333e14cee8b2d80f07ceaa25ca49b05451803' 
  AND token = 'NQd6wtt1tdBiXbhbxbSBPxqrYDsT1gHgMqDEy1Ka6Ew=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}