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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81b157270b969bf3b013b4acef4336ab2bfab75b2fb5383faf90f42cb8c03197' 
  AND token = 'NmptGSyLVBwssGJWjYT9k+oBTNNiATSKf3gE3ALT6SE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}