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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46442cb7c02ea3ec861c78754418a1f7af7ab6b4b524798897c95127e8819ee3' 
  AND token = 'fIvBFD6i12f1dm/6MSe+NRQ7LzO11QGvjJCzWwZC4i4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}