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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '381ac0d180a9bac12b9f171f60e9cba7243dd0f25a6001a11bcbb21ff6eef8c7' 
  AND token = 'G+xYa26HrdWJ/4qOfcvTGmWe1gURpQvV8HoEZJhONEs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}