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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '74cd64e914e8c3f88d484b797a3ee4208f1ab5b4aa6e0f842e43977093a7c593' 
  AND token = 'lUGTOmjvrll1FE68+lxFiMNW/xKuIbb3Ab8RWVBQL0Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}