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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd46fcd0f036cc24d38fee2e938f90a758216d00fcb38486ea3467d7fed2d3030' 
  AND token = 'f6oaP+SOs/rAFf3b/yQyd4zoMXI4o1nqWqNXoK+kAD8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}