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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4265ffca1d3f94bb2f2ba244795932d4f8840b89d3519ff9a3b9b0b8e63afbe8' 
  AND token = 'SYzu7bjAk/xdKL+EUUFE6aM3PtCIdvAvSnD7jHd+HmA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00046

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}