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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '11526a6d54155340e9eb944665e2dc9a453f91c7fcf0fb996f12740a08eab06d' 
  AND token = 'O3aHwXjGDyzq+V9BW+O9FE1KLEAsGOqTCEigMaEIZAI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00049

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}