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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a45c68efaf1ea60bf2969e44ea36b87287523b79cc0f673ad3397d7a05299972' 
  AND token = 'spPxD4G4BT/TYr9nxoI/yqFuQJ+yY0bWBfWbeUnMqSc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}