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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cb37cdc8c110143b21c98a2917bc6ee228c383b25a29169492ee6b375e0f0a46' 
  AND token = 'eeHx0stwrOMt3h66wFIHNqRmPt5BuPg2d6ZKNRrwhTk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}