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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80668a02f6a2c0469248ce89a45e13ce6d077b2f16735d3edb7989e225e69da0' 
  AND token = '6o6l5G1BiwFg1Yn0/dISw4awSIqXk2uw7zFdJ765uPs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}