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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5ef39e7ac58b0d9cbad7ed367dea780e877017a3f61b5d55416584e7c4236c29' 
  AND token = 'JEs20GuJcK/lSFuV9VvH3FXVFEmR7cW4qIuhNExCx7A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}