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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '448a517d8ba9fec7e589b7fb40c147011272f4faa9caecf38cd1df495f21f5e4' 
  AND token = 'dNhZTp60+Ah1+t/eW9Va88v68btQRNuqMS4Xrn/pQ+A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}